Our Pipeline

Visionary

Our pipeline is growing and ambitious, starting with a phase 1 clinical trial delivering CART-ddBCMA to patients with relapsed or refractory multiple myeloma.

Our Current Pipeline

Discovery
Preclinical
Phase 1P1
Phase 2P2
Phase 3P3

DDBCMA

CART-ddBCMA is a cell therapy product candidate involving patient-derived, or autologous, T cells that have been genetically modified to recognize and kill specific cells expressing BCMA, a target antigen for multiple myeloma. This candidate utilizes our D-Domain in place of the traditional scFv binding domain of conventional cell therapies. Arcellx’s CART-ddBCMA has been granted Fast Track Designation, Orphan Drug Designation, and Regenerative Medicine Advanced Therapy Designation by the US Food and Drug Administration for the treatment of relapsed or refractory multiple myeloma.

DDBCMA

iMMagine-2 is the expansion study within earlier lines of therapy for multiple myeloma. Upon completion of enrollment of the pivotal trial for approval of CART-ddBCMA, we plan to initiate enrollment of our iMMagine-2 study to evaluate efficacy of CART-ddBCMA in earlier line populations with multiple myeloma.

MM-iACLX001-BCMA

ACLX-001 is in development for the treatment of relapsed or refractory multiple myeloma. ACLX-001 is composed of ARC-T cells and a bivalent SparX protein-targeting BCMA. This SparX-BCMA protein utilizes the same antigen binding domain as CART-ddBCMA.

Discovery
Preclinical
Phase 1P1
Phase 2P2
Phase 3P3

AML-MDS-ACLX002-CD123

ACLX-002 is an ARC-SparX platform cell therapy using a SparX protein targeting CD123 for the treatment of relapsed or refractory acute myeloid leukemia (AML) and high-risk myelodysplastic syndrome (MDS).

AML-MDS-AML234

Arcellx has also identified a second antigen target associated with AML/MDS. This program is in advanced preclinical development.

AML-MDS-AML234

Arcellx is continuing to identify additional high-priority antigen targets.

AML-MDS-AML234

Arcellx is continuing to identify additional high-priority antigen targets.

Discovery
Preclinical
Phase 1P1
Phase 2P2
Phase 3P3

ST-SCLC

Arcellx intends to develop multiple assets and novel technology to combat a variety of solid tumor indications while leveraging the strengths of each of our existing ddCAR and ARC-SparX therapeutic platforms. We anticipate our initial targets will be in hepatocellular carcinoma (HCC) and small cell lung cancer (SCLC).

ST-HCC

Arcellx intends to develop multiple assets and novel technology to combat a variety of solid tumor indications while leveraging the strengths of each of our existing ddCAR and ARC-SparX therapeutic platforms. We anticipate our initial targets will be in hepatocellular carcinoma (HCC) and small cell lung cancer (SCLC).

Therapeutic Focus Area: Oncology

Arcellx is focused on the development of cell therapies in cancers with a particularly high need. We are developing cell therapy treatments for multiple myeloma, acute myeloid leukemia, myelodysplastic syndrome, and solid tumors.

Patients and their loved ones can find additional information here.

Multiple myeloma (MM) is a blood cancer that may cause cancerous tumors in bone and soft tissue. Multiple myeloma is the third most common hematological malignancy in the United States and Europe. Despite the development and use of multiple new therapies, the 5-year survival rate is approximately 50% as multiple myeloma remains incurable in most patients.

Acute myeloid leukemia (AML) is a blood and bone cancer that arises from bone marrow stem cells that have accumulated genetic mutations, causing the mutated cells to grow uncontrollably. CAR-T therapies are being deployed with specificity for various targets including CD33, CD123, FLT3, CCL1, CD19, IL1RAP, and NKG2DL. The 5-year survival rate for acute myeloid leukemia patients is approximately 29%.

Myelodysplastic syndrome (MDS) is a disease closely related to AML in which a population of abnormal myeloid stem cells develops in the bone marrow. Like AML, MDS impacts the elderly, with patients often diagnosed in their 70s. An estimated one-third of MDS patients progress to AML. Patients are typically treated with chemotherapy. While stem cell transplant may cure MDS, toxicities associated with the treatment significantly limit patient eligibility.

Arcellx intends to develop multiple assets and novel technology to combat a variety of solid tumor indications while leveraging the strengths of each of our existing ddCAR and ARC-SparX therapeutic platforms. We anticipate our initial targets will be in hepatocellular carcinoma (HCC) and small cell lung cancer (SCLC).

Clinical Trials

At this time, Arcellx’s investigational therapies can only be accessed through participation in a clinical trial. For detailed information on our ongoing clinical studies in multiple myeloma, please click here.

Scientific Publications

Contact Us

Stay at the forefront of our advancements
in the battle against cancer.

*Required field

By clicking SUBMIT, you agree to our Terms & Conditions and Privacy Policy, and to receive information from Arcellx, its affiliates, service providers, and co-promotion partners.