The D-Domain is a small, stable, fully synthetic binding agent with a hydrophobic core.
Its unique structure, when used in CARs, can potentially enable higher transduction efficiency, high cell surface expression, and low tonic signaling, and it is designed to improve target specificity while enhancing binding affinity.
The unique properties of D-Domain allow us to generate diverse libraries of proprietary target-binding domains and serve as the foundation of our proprietary ddCAR and ARC-SparX platforms.